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Women's Health: A FUNCTIONAL MEDICINE THERAPEUTIC APPROACH OF LEIOMYOMA OR FIBROIDS Tags: Kenor International Kenor Essay Research Women's Health Woman's Health Fibroid Leiomyoma Dr Keny F Bastien Horomones Hysterectomy
 

 

Fibroids or leiomyoma is a most common benign tumor found in females, most likely during the middle and later fertility years. They can grow and cause painful menstruation, difficult sexual intercourse, urinary frequency and urgency. Although benign and asymptomatic, for most of the frequent cases of leiomyoma, the scientific medical community estimates there could be only 0.1-0.5% malignant forms of fibroids.

3% of the fibroids can be located in a submucosal position interfering with the lining and the ability of the embryo to implant. There are several types of fibroids: submucosal, subserosal and cervical fibroids. The submucosal fibroids are located in the muscle beneath the endometrium invading the uterine cavity . Any benign lesion in that area can lead to infertility. The subserosal is found underneath the surface of the uterus and can enlarge to become a parasitic pedonculated leiomyoma detached from the uterus.

Leiomyoma or fibroids are often multiple. They appear round, well circumscribed. They usually look like solid nodules white or tan. They are made of cells uniform in size and shape with scarce mitosis. It also happens that they show atypical and mitotical activity. Leiomyoma submucosal, subserosal, or intramural, develop in the corpus of the uterus. Submucosal fibroids are more likely to cause bleeding, necrosis and infection.

Specific mutations of the MED12 protein has been observed in 70% of fibroid cases. many other factors such as genetic affiliation, fertlity treatment, xenoestrogens are identified as possible causes of fibroids. Estrogen and progesterone, seem to be involved in the growth of fibroidsas well as other factors such as: being of african descent, polycystic ovary syndrome, diabetes, hypertension, obesity.

It has been observed that fibroids may grow or not grow during pregnancy. They inevitably increase in size with exogenous estrogen stimulation through menopausal estrogen replacement therapy or the use of oral contraceptives.

Estrogen and progesterone mitotic effects can be put in relation with prolactin signalling that controls the activity of the respective nuclear receptors. Both hormones influence the fibroid growth factors, the cytokines, the apoptotic mechanisms and the secretion of other hormones.

Estrogen promotes growth by up- regulating P53 enhancing the anti-apoptotic PcP4 function and antagonizing PPAR-gamma signalling. Progesterone up-regulates IGF-1, EGFR, TGF-beta1, TGF beta3 and PDGF, Bcl-2 while down regulates TNF-alpha causing the proliferation of leiomyoma cells. To add to our confusion, it has been observed that progesterone counteracts leiomyoma growth by down regulating IGF-1. The same hormone shows antagonistic behavior in relation with leiomyoma growth.

High concentration and activity of TGIF are observed in leiomyoma. The same agent behaves as a potential repressor of TGI- beta pathways in myometrial cells. ER-alpha and ER -beta and progesterones receptors are particularly active in premenopausal fibroids. ER-alpha genotype presents a significant correlation with the incidence and the size of leiomyoma among white females. This same correlation is far much higher for premenopausal black females with high incidence of fibroids.

Functional medicine favors and tends to enhance and reinforces the apoptosis of leiomyoma cells. PPAR receptor activation causes the inhibition of TGF-beta 3 expression and increases the apoptosis of leiomyoma cells.

Instead of fully accepting the statistic evidence established for 2.5 fold risk for first degree relative and nearly 6-fold risk when considering early onset cases of leiomyoma, we consider that the heredo-nutritional approach would do greater justice to the scientific truth. Since there is involvement of extracellular signalling pathways such as ERK1 and ERK2 which in fibroids are strongly influenced by hormones, we are lead to evaluate the direct impact of nutrition, and more specifically the Cori cycle on the growth of leiomyoma.

The endocrine implication invites to take into account the lipid metabolism as one of the major contributing factor of leiomyoma formation. As in cardiovascular disease, two main types of blood fat could be involved in leiomyoma: cholesterol and triglycerides. Cholesterol is a four ringed molecule, a sterol, precursor of various hormones, such as corticosteroids and 17-keto steroids. The body can make cholesterol from the products of sugar metabolism and can use the cholesterol available in food. If more is available from food, less is made in the body. The body makes most of its cholesterol from the sugar found in food. The saccharine disease or the slavery diet, being high in starch and sugar(sucrose), could play a major role in the creation of too much cholesterol in the body. It is also responsible for excess of calories leading to obesity. Cholesterol is one of the main components of atherosclerotic plaques.

Whenever a leiomyoma grows rapidly under high estrogen influence, it may outstrip its nutrition supply from nearly blood vessels resulting in the degeneration and death of the oxygen deprived tissue

Black females present a higher prevalence of ER-alpha and ER-beta, and progesterone receptors expression in premenopausal fibroids. This could be a clear indicator of a particular metabolic pathway modification associated with the eating pattern, Dr. Keny Bastien MD,MA., refers to as the slavery diet or the Saccharine disease diet ( Orthomolecular Medicine for Physicians).

It appears that atherosclerotic injury to uterine blood vessels associated with inflammation could be a causal factors of fibroids, as well as endocrine factors such as Angiotensine II via angiotensine II type 1 receptors. Aromatase and 17 Beta hydroxy-steroid-deshydrogenase are aberrantly expressed in fibroids converting androstenedione into estradiol. Aromatase secretion is abnormally high in african-american women compare to caucasian females.

There could be according to our investigation a definite hormonal influence and the interferences of carbohydrate and lipid metabolisms in the leiomyoma growth. The Functional medicine therapeutic approach to shrink or remove the fibroid differs theoretically and clinically from the allopathic recommendations.

Functional medicine suggests :

1) The restoration of the optimal estrogen-estrogen and estrogen-progesterone ratios as indicated by Dr . Maria Bell in the treatment of hormono-dependent cancers.

2) The use of Nicotinic acid as an inhibitor of cholesterol synthesis, ( Illingworth, Roger, Phillipson, Rapp and Connor 1981), resulting from the Cori cycle associated with the Saccharine disease diet.

3) The reduction of the cellular metabolic wastes, usually accumulated in the interstitial fluids and causing their substantial pH decrease, and increase viscosity which can be made possible with an alkaline diet. ( Dr. Keny F. Bastien: Common Foods with Wonderful healing Properties, Kenor International 2003).

4) The complete elimination of bread ( whole wheat or white), rice ( brown or white) and sugar from the diet.

5) Large intake of antioxidants and wide spectrum enzymes complex between meals to help break down the partially undigested or processed foods or metabolic wastes.

6)Exercise

7) Improved sleeping pattern for the correction of the hormones cycles.

 

It's obvious that a lot more could be said regarding the treatment of leiomyoma without surgical procedures. Functional medicine only aknowledges that hysterectomy and other type of ablation or leiomyomectomy for therapeutic purposes , usually do not remove the conditions that create the pathological dysfunction. Scientifically it is more beneficial to preserve the anatomical wholeness and restore the integrity of the body fonctions for the patient well being.

 

Dr.Keny Bastien M.D., M.A., Kenor International.
Orlando, Florida,USA.
August 2, 2013

 

 

Abram Hoffer, M.D., Ph.D. Orthomolecular Medicine for Physicians The Keats library /Vol 2. Keats 1989.

The Burton Goldberg Group. Alternative medicine. The future medicine publishings.

Carl C. Pfeiffer MD, PhD, Pierre Gonthier MA. Equilibre Psychobiologique & Oligo Aliments. Equilibres aujourd'hui. 1988.

Elizabeth Lipski, M.S.,C.C.N. Digestive Wellness. Keats 1996

Dr. Keny Bastien M.D., M.A. Common Foods with Wonderful Healing Properties. Kenor International Edition, Florida, USA. 1998.

Elaine Marieb, Anatomie et Physiologie Humaines. Editions De Boeck Universite. Canada.1993.

Krupp Chaton, Current Medical Diagnosis & Treatment. Lange 1984.

Patsy Bostick Reed, Nutrition an applied science. West publishings, 1980.

 

 

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